Do Si Dos

Genetics and Origin

The Do-Si-Dos strain was born from cannabis royalty. Archive Seed Bank in Portland, Oregon crafted this cultivar by crossing a Girl Scout Cookies phenotype (sometimes noted as OG Kush Breath, or OGKB) with Face Off OG — a devastatingly potent OG Kush descendant prized for its sedative, full-body effects.

The GSC side contributes the cookie-dough sweetness, earthy complexity, and Durban Poison-derived terpene diversity that runs through the Cookies genetic library. Face Off OG layers on raw indica potency, dense bud structure, and the gasoline-tinged OG funk that experienced consumers crave. The resulting 70/30 indica-dominant profile quickly earned Do-Si-Dos competition awards and a permanent spot on top-shelf dispensary menus across the country.

Notable phenotypes — especially #9, #18, and #22 — each express slightly different terpene ratios while maintaining the strain's signature knockout power.

Appearance, Aroma, and Flavor

Do-Si-Dos is one of the most visually stunning strains on any dispensary shelf. The buds are dense, compact, and practically drip with oversized trichomes that give them a frosty, crystalline appearance.

Lime-green leaves are threaded with deep lavender and purple hues, while bright amber-orange pistils weave throughout—creating a color palette that looks almost too beautiful to break apart.

The aroma opens with a sweet, doughy cookie-batter note from its GSC heritage, quickly layered with pungent earthy fuel and OG funk. A limonene-driven citrus brightness lifts through the middle, adding unexpected complexity.

On the inhale, Do-Si-Dos delivers a smooth, sweet flavor with notes of mint and fresh pine; the exhale reveals a spicy, peppery finish from its robust caryophyllene content, rounded by a floral linalool softness.

Terpene Profile

The Do-Si-Dos strain features a complex terpene profile with total terpene content typically ranging from 2.0-3.5% in top-shelf batches.

The dominant terpenes include: Limonene (dominant): The lead terpene delivers a bright, citrusy sweetness that lifts the cookie-dough base. Limonene is associated with mood elevation and may help counteract THC-induced anxiety — a valuable trait given Do-Si-Dos' high potency.

Beta-Caryophyllene (0.3-0.8%): Contributing spicy, peppery warmth, caryophyllene is the only terpene that directly binds to CB2 receptors. This unique property may support anti-inflammatory and pain-relieving effects, enhancing the strain's deep relaxation.

Linalool (0.2-0.5%): The "spa terpene" adds floral, lavender-like softness and potential sedative properties.

Supporting terpenes: Myrcene contributes earthy depth and may potentiate THC’s effects, while humulene adds dry, hoppy bitterness and potential appetite-modulating properties.

Together, these terpenes create the signature cookie-gas-lavender experience through the entourage effect.

Effects and Experience

The Do-Si-Dos strain hits like a freight train wrapped in velvet. The onset is immediate and cerebral—a euphoric rush of happiness and mental clarity that lights up the mind within the first few minutes. But this head high is only a prelude: within 15-20 minutes, the indica-dominant hybrid genetics take hold, unleashing a wave of full-body relaxation that cascades from the head downward.

Tension in the neck, shoulders, and lower back dissolves as users describe a distinctive "melting" sensation—like sinking deeper into whatever surface they’re resting on.

At higher doses (especially with THC levels reaching 25-30%), Do-Si-Dos can induce profound couch-lock and sedation, gently guiding users toward sleep. This is an evening strain—perfect for unwinding with a favorite movie, cozy blanket, and zero obligations.

Medical Applications

Do-Si-Dos has earned a reputation for delivering medical-grade body effects—a quality inherited directly from its Face Off OG parentage. Medical cannabis patients commonly reach for this strain to address chronic pain, muscle spasms, and inflammation, as the caryophyllene-linalool terpene stack may work synergistically with high THC levels to promote physical relief.

The strong sedative properties are commonly associated with managing insomnia and sleep latency—many patients report falling asleep faster and staying asleep longer after evening use. The euphoric onset may also help manage symptoms of stress, anxiety, and depression, though patients prone to THC-related anxiety should start with low doses given the strain’s extreme potency.

Appetite stimulation is another frequently reported benefit, making Do-Si-Dos a potential option for patients dealing with appetite loss. Always consult a healthcare professional before using cannabis medicinally.

Cannabinoid Content

The Do-Si-Dos strain packs a seriously potent cannabinoid profile. THC content typically ranges from 20-30%, with top-shelf phenotypes like #9 and #22 consistently testing at the upper end—making this one of the more powerful indica-dominant hybrids on the market.

CBD levels are low, generally below 1%, so the experience is primarily THC-driven. Trace amounts of CBG (0.02-0.1%) and CBN may also be present, contributing subtle therapeutic nuance.

Cannabinoid percentages vary by batch, cultivator, and phenotype—always check the COA for your product.

Similar Strains

If Do-Si-Dos' deep relaxation and cookie-family flavor resonate with you, these strains share overlapping genetics or similar profiles: GMO Cookies: Another GSC descendant crossed with Chemdawg, GMO Cookies (also called Garlic Cookies) delivers even heavier sedation with a pungent garlic-diesel-earth flavor—perfect for experienced consumers who love potent indicas.

Northern Lights: A classic pure indica with a similarly sedative body high and sweet-earthy aroma. Northern Lights offers a gentler entry point for those who find Do-Si-Dos' THC levels overwhelming.

Gelato: Sharing Cookie Fam genetics (Sunset Sherbet x Thin Mint GSC), Gelato provides a slightly more balanced, uplifting experience with dessert-forward flavors that complement Do-Si-Dos beautifully.

White Widow: A legendary balanced hybrid with heavy trichome production and a euphoric-to-relaxed effect arc that appeals to the same evening consumers.

Conclusion

In the crowded world of cookie-family cultivars, Do-Si-Dos occupies a unique niche: it is the heavy hitter, the nightcap, the strain you reach for when nothing else is strong enough to quiet both the mind and body.

Archive Seed Bank created something special by pairing GSC’s complex sweetness with Face Off OG’s knockout indica power, and the result has earned competition awards and a permanent place on top-shelf menus nationwide. Ready to experience unmatched relaxation?

Browse the full HyperWolf strain collection and add the Do-Si-Dos strain to your next delivery order.

Frequently Asked Questions

Is Do-Si-Dos indica or sativa?

Do-Si-Dos is an indica-dominant hybrid with about 70% indica and 30% sativa genetics. It delivers deep body relaxation and sedation, primarily due to its strong indica heritage, while the sativa component provides a brief euphoric cerebral onset.

How strong is the Do-Si-Dos strain?

The Do-Si-Dos strain is very potent, typically containing THC levels between 20-30%. Notably, the #9 and #22 phenotypes frequently exceed 25% THC. This makes Do-Si-Dos best suited for users with moderate-to-high THC tolerance seeking powerful effects.

What does Do-Si-Dos taste like?

Do-Si-Dos offers a complex flavor profile: sweet cookie dough, earthy OG funk, citrus brightness, and minty pine are present on the inhale, followed by a spicy pepper finish on the exhale. The aroma includes floral lavender notes from its linalool terpene content.

What are the dominant terpenes in Do-Si-Dos?

The three dominant terpenes in Do-Si-Dos are limonene (citrusy), caryophyllene (spicy), and linalool (floral). Myrcene and humulene add earthy depth and may assist with appetite modulation.

Is Do-Si-Dos good for sleep?

Do-Si-Dos is widely recognized for strong sedative properties at higher doses. Its indica dominance and calming linalool content make it a popular nighttime choice among those managing insomnia.

What strains are related to Do-Si-Dos?

Do-Si-Dos connects to Gelato, Sunset Sherbet, Cherry Pie, Wedding Cake via GSC parentage. Offspring include Dosi-Cake and Dosidos x Gelato.