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The Truth About 1:1 Ratios: THC, CBD, and Their Combined Effects

A 1:1 CBD to THC ratio in cannabis products means there’s an equal amount of THC and CBD in the mix, creating a balanced effect that’s quite popular among users. THC, or tetrahydrocannabinol, is the compound responsible for the high, while CBD, or cannabidiol, offers calming and therapeutic effects without the psychoactive kick. So, does 1:1 get you high?

Well, the answer is a bit nuanced. The presence of CBD tends to mellow out the high caused by THC, leading to a more balanced and often more enjoyable experience. People are drawn to 1:1 ratios because they can reap the benefits of both compounds, like pain relief and reduced anxiety, without the intense high that high-THC products can bring.

In this blog, we’ll dive into how these products work, explore the combined effects of THC and CBD, and discuss why this combination has captured so much interest.

bright green flowering cannabis plant

The Science Behind THC and CBD

THC and CBD, while both cannabinoids found in the medicinal cannabis plant, interact with the body’s endocannabinoid system in different ways.

THC binds directly to CB1 receptors in the brain, causing the psychoactive effects or the “high” that users feel. CBD, on the other hand, doesn’t bind to these receptors in the same way; instead, it modifies the receptor’s ability to bind to THC and influences other receptors throughout the brain and body.

This interaction results in potential benefits like pain relief, anti-inflammatory effects, reduced anxiety, and more without the intense psychoactive experience. Together, these compounds create a synergistic effect, often referred to as the “entourage effect,” enhancing each other’s positive impacts while mitigating some of the less desirable effects.

How 1:1 Ratios Interact with the Body

“When CBD and THC are present in equal parts, they create a unique interaction within the body’s endocannabinoid system. The THC component binds to CB1 receptors in the brain, delivering a mild psychoactive effect, while the CBD component modifies the receptor’s response to THC and influences a range of other receptors. This balanced ratio can help counteract some of the more intense effects of THC, leading to a smoother and more controlled experience.

Such a balanced interaction can be especially therapeutic, offering potential relief from pain, inflammation, and anxiety without overwhelming psychoactive effects. This makes 1:1 medical marijuana products a popular choice among those seeking a harmonious blend of benefits from both compounds. Additionally, THCa, a non-psychoactive precursor to THC, may also contribute to this therapeutic balance, enhancing the overall effectiveness and providing additional anti-inflammatory and neuroprotective benefits.”

a person applying gold cannabis oil

Common Forms of 1:1 Products

When it comes to 1:1 medical cannabis products, there’s a variety to choose from, each offering its own range of beneficial effects.


These are liquid cannabis extracts that you can take sublingually (under the tongue) or add to food and drinks. Tinctures are known for their quick absorption and ease of dose control.

  • Pros: Fast-acting, easy to dose, versatile (can be taken directly or added to foods)
  • Cons: Strong taste, can be more expensive than other forms


These include gummies, chocolates, and other ingestible products infused with cannabis. Edibles offer long-lasting effects but can take a while to kick in.

  • Pros: Long-lasting effects, discreet, tasty options
  • Cons: Delayed onset of effects, harder to dose precisely, can be tempting to over-consume


These are creams, balms, or lotions infused with cannabis, designed for external use. Topicals are popular for localized pain relief and don’t provide any psychoactive effects.

  • Pros: No psychoactive effects, targets localized pain or skin issues, easy to apply
  • Cons: Limited to external use only, effects are localized and may not help with issues like anxiety or insomnia

How to Choose the Right Form for Your Needs

Choosing the right form of 1:1 product depends on what you’re looking to get out of it. If you need quick relief and precise dosing, tinctures might be your best bet.

For sustained relief with a more discreet option, edibles could be the way to go, though you’ll need to be patient for the effects to kick in. On the other hand, if you’re targeting specific areas of pain or inflammation without any psychoactive effects, topicals are an excellent option.

Understanding your needs and preferences will help you make the best choice.

User Experiences with 1:1 Ratios

Many users report that 1:1 products provide a balanced and manageable experience. People often find they maintain clarity and focus while enjoying relief from stress, pain, or anxiety. The mellow high from the THC, tempered by the calming effects of CBD, is frequently cited as being comfortable and functional.

However, experiences can vary significantly depending on how the 1:1 product is consumed. Users of tinctures often notice quicker relief and find it easier to control their doses.

Those who prefer edibles usually talk about the extended duration of effects, but caution against the slower onset, which can sometimes lead to taking too much initially.

Topical users usually focus on the localized relief they get without experiencing any sort of systemic high, making it easier to go about daily activities while addressing specific pain points.

Medical Perspectives on 1:1 Ratios

Healthcare professionals are increasingly recognizing the potential benefits of 1:1 THC and CBD ratios for various medical conditions.

Many doctors and medical experts suggest that these products can be particularly effective for patients with chronic pain, inflammation, anxiety, and certain neurological disorders like epilepsy. The balanced combination of THC and CBD appears to offer a therapeutic effect without the overwhelming psychoactive experience often associated with higher THC products.

Several research studies and clinical trials have shown promising medicinal results, indicating that 1:1 ratios can improve the quality of life for patients dealing with conditions such as multiple sclerosis, arthritis, and even some forms of cancer.

This growing body of evidence has encouraged a broader acceptance and integration of 1:1 products in medical treatment plans.

pink cannabis gummies next to flower nugs

Potential Benefits of 1:1 Products

1:1 THC and CBD products offer a range of potential benefits, thanks to the synergistic effects of the two compounds.

One of the most notable advantages is pain relief, as the combination can help reduce inflammation and alleviate chronic pain more effectively than THC or CBD alone. Users often report that these products also provide significant anxiety reduction, making them a great option for those struggling with stress or nervousness.

Moreover, the balanced ratio can be less intoxicating compared to high-THC products, allowing individuals to maintain better cognitive function and daily productivity. For those dealing with conditions like epilepsy, multiple sclerosis, or arthritis, the 1:1 ratio can offer a therapeutic alternative that works gently yet effectively, without the overwhelming psychoactive effects that sometimes accompany higher doses of THC.

Possible Side Effects and Risks

While 1:1 products generally offer a more balanced and manageable experience, they are not without possible side effects. Commonly reported issues include dry mouth, dizziness, and mild psychoactive effects, although these are usually less intense compared to high-THC products.

People with a history of mental health disorders or those who are pregnant should exercise caution and consult healthcare professionals before using these products. To mitigate potential risks, it’s essential to start with a low dose and gradually increase it, ensuring you monitor how your body responds.

Consuming in a safe environment and avoiding activities requiring full cognitive function, like driving, can also help reduce risks and enhance your experience with 1:1 THC and CBD products.

cannabis tincture added to tea cup

Does 1:1 Get You High? – Conclusion

In summary, 1:1 THC and CBD products offer a balanced approach that combines the benefits of both cannabinoids. Whether you’re using tinctures, edibles, or topicals, it’s essential to consider your specific needs and desired outcomes. Tinctures provide quick relief and precise dosing, making them ideal for immediate effects. Edibles offer prolonged relief but require patience due to their slower onset. Topicals are fantastic for localized pain relief without any psychoactive effects. From a medical perspective, the balanced ratio is proving beneficial for managing chronic pain, anxiety, and various neurological conditions.

For those considering 1:1 products, start with a low dose to understand how your body reacts, especially if you are new to cannabis or have specific health concerns. Always consult with a healthcare professional if you have any doubts.

In terms of psychoactive effects, while 1:1 products can get you high, the experience is generally milder and more manageable compared to high-THC products. This makes them a great option for those looking for therapeutic benefits without an overwhelming high. Ultimately, 1:1 ratios offer a versatile and balanced option for both new and experienced users.

Frequently Asked Questions

1. What is a 1:1 high?

A 1:1 high refers to the effects you experience from a cannabis product that has an equal ratio of THC to CBD. This balanced mix results in a more mellow, manageable experience compared to high-THC products. The THC component provides a mild psychoactive effect, while the CBD works to counteract some of the THC’s intensity, resulting in a high that many describe as relaxed and functional.

2. What does 2:1 mean in edibles?

When you see an edible product labeled as 2:1, it indicates that the product contains twice as much CBD as THC. For example, if an edible has 10 mg of THC, it will contain 20 mg of CBD. This ratio aims to provide the therapeutic benefits of both cannabinoids, with a stronger emphasis on the calming and anti-inflammatory properties of CBD, while still allowing for a mild psychoactive effect from the THC.

3. What is a high CBD percentage?

A high CBD percentage typically refers to cannabis strains or products where CBD content significantly outweighs THC content. Often, this means CBD levels of 10% or higher. These high-CBD products are favored for their therapeutic benefits without the intense psychoactive effects associated with high-THC products. They are ideal for individuals seeking relief from conditions like anxiety, pain, and epilepsy, while maintaining clear-headedness and functionality.